Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 758736..759238 Replicon chromosome
Accession NZ_CP116145
Organism Escherichia coli strain DETEC-P622

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag PIB88_RS03900 Protein ID WP_000767819.1
Coordinates 758736..758990 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag PIB88_RS03905 Protein ID WP_001259253.1
Coordinates 758987..759238 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB88_RS03875 (754554) 754554..755012 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
PIB88_RS03880 (755229) 755229..756587 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
PIB88_RS03885 (756577) 756577..756639 - 63 WP_010723108.1 membrane protein YoeI -
PIB88_RS03890 (756854) 756854..757783 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIB88_RS03895 (757829) 757829..758653 - 825 WP_000754737.1 SDR family oxidoreductase -
PIB88_RS03900 (758736) 758736..758990 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIB88_RS03905 (758987) 758987..759238 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIB88_RS03910 (759521) 759521..759571 + 51 WP_001364200.1 his operon leader peptide -
PIB88_RS03915 (759717) 759717..760616 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
PIB88_RS03920 (760622) 760622..761926 + 1305 WP_001296211.1 histidinol dehydrogenase -
PIB88_RS03925 (761923) 761923..762993 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
PIB88_RS03930 (762993) 762993..764060 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 754554..755012 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T268151 WP_000767819.1 NZ_CP116145:c758990-758736 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT268151 WP_001259253.1 NZ_CP116145:c759238-758987 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References