Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2275..2836 Replicon plasmid pDETEC33
Accession NZ_CP116125
Organism Escherichia coli strain DETEC-P666

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PIB57_RS24400 Protein ID WP_013009346.1
Coordinates 2558..2836 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag PIB57_RS24395 Protein ID WP_271291420.1
Coordinates 2275..2535 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB57_RS24385 (PIB57_24390) 495..1367 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
PIB57_RS24390 (PIB57_24395) 2062..2220 + 159 WP_000829588.1 hypothetical protein -
PIB57_RS24395 (PIB57_24400) 2275..2535 + 261 WP_271291420.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PIB57_RS24400 (PIB57_24405) 2558..2836 + 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
PIB57_RS24405 (PIB57_24410) 3032..3328 - 297 WP_001419651.1 hypothetical protein -
PIB57_RS24410 (PIB57_24415) 3673..4260 + 588 WP_001418189.1 serine acetyltransferase -
PIB57_RS24415 (PIB57_24420) 4542..5135 - 594 WP_001401779.1 ProQ/FINO family protein -
PIB57_RS24420 (PIB57_24425) 5489..6835 + 1347 WP_001132021.1 protein YagA -
PIB57_RS24425 (PIB57_24430) 7156..7674 + 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..86916 86916
flank IS/Tn - - 7693..8913 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T268114 WP_013009346.1 NZ_CP116125:2558-2836 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9871.17 Da        Isoelectric Point: 6.4651

>AT268114 WP_271291420.1 NZ_CP116125:2275-2535 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSGMK

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References