Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4037145..4037838 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIC92_RS19780 Protein ID WP_000415584.1
Coordinates 4037542..4037838 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIC92_RS19775 Protein ID WP_000650107.1
Coordinates 4037145..4037540 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS19765 (4033009) 4033009..4035267 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
PIC92_RS19770 (4035405) 4035405..4037012 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PIC92_RS19775 (4037145) 4037145..4037540 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIC92_RS19780 (4037542) 4037542..4037838 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIC92_RS19785 (4038043) 4038043..4038525 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PIC92_RS19790 (4038578) 4038578..4038970 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIC92_RS19795 (4039122) 4039122..4039781 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIC92_RS19800 (4039778) 4039778..4041127 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIC92_RS19805 (4041173) 4041173..4041505 - 333 WP_000917685.1 DUF2645 family protein -
PIC92_RS19810 (4041824) 4041824..4042405 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PIC92_RS19815 (4042436) 4042436..4042750 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4028682..4037838 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T268072 WP_000415584.1 NZ_CP116115:c4037838-4037542 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT268072 WP_000650107.1 NZ_CP116115:c4037540-4037145 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References