Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2862146..2862648 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PIC92_RS14285 Protein ID WP_000767822.1
Coordinates 2862146..2862400 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIC92_RS14290 Protein ID WP_001259255.1
Coordinates 2862397..2862648 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS14265 (2858639) 2858639..2859997 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
PIC92_RS14270 (2859987) 2859987..2860049 - 63 WP_010723108.1 membrane protein YoeI -
PIC92_RS14275 (2860264) 2860264..2861193 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIC92_RS14280 (2861239) 2861239..2862063 - 825 WP_000754737.1 SDR family oxidoreductase -
PIC92_RS14285 (2862146) 2862146..2862400 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIC92_RS14290 (2862397) 2862397..2862648 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIC92_RS14295 (2862931) 2862931..2862981 + 51 WP_001364200.1 his operon leader peptide -
PIC92_RS14300 (2863127) 2863127..2864026 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
PIC92_RS14305 (2864032) 2864032..2865336 + 1305 WP_001445483.1 histidinol dehydrogenase -
PIC92_RS14310 (2865333) 2865333..2866403 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
PIC92_RS14315 (2866403) 2866403..2867470 + 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T268069 WP_000767822.1 NZ_CP116115:c2862400-2862146 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT268069 WP_001259255.1 NZ_CP116115:c2862648-2862397 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References