Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2289697..2290259 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag PIC92_RS11305 Protein ID WP_000605675.1
Coordinates 2289981..2290259 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PIC92_RS11300 Protein ID WP_000781370.1
Coordinates 2289697..2289981 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS11285 (2284878) 2284878..2287925 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
PIC92_RS11290 (2287938) 2287938..2288822 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
PIC92_RS11295 (2288815) 2288815..2289468 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
PIC92_RS11300 (2289697) 2289697..2289981 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PIC92_RS11305 (2289981) 2289981..2290259 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIC92_RS11310 (2290445) 2290445..2291455 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
PIC92_RS11315 (2291589) 2291589..2293286 - 1698 WP_000433460.1 malate dehydrogenase -
PIC92_RS11320 (2293443) 2293443..2293580 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
PIC92_RS11325 (2293682) 2293682..2293897 - 216 WP_000495766.1 biofilm-dependent modulation protein -
PIC92_RS11330 (2294242) 2294242..2294673 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T268064 WP_000605675.1 NZ_CP116115:c2290259-2289981 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT268064 WP_000781370.1 NZ_CP116115:c2289981-2289697 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References