Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1247394..1248073 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag PIC92_RS05995 Protein ID WP_000057523.1
Coordinates 1247394..1247696 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag PIC92_RS06000 Protein ID WP_000806442.1
Coordinates 1247732..1248073 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS05975 (1242657) 1242657..1243877 - 1221 WP_001773866.1 fosmidomycin MFS transporter -
PIC92_RS05980 (1244095) 1244095..1245747 + 1653 WP_001773867.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
PIC92_RS05985 (1245784) 1245784..1246263 - 480 WP_001538397.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
PIC92_RS05990 (1246467) 1246467..1247261 - 795 WP_001538398.1 TraB/GumN family protein -
PIC92_RS05995 (1247394) 1247394..1247696 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIC92_RS06000 (1247732) 1247732..1248073 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
PIC92_RS06005 (1248131) 1248131..1250635 - 2505 WP_000083948.1 copper-exporting P-type ATPase CopA -
PIC92_RS06010 (1250897) 1250897..1251829 + 933 WP_001538399.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T268063 WP_000057523.1 NZ_CP116115:1247394-1247696 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT268063 WP_000806442.1 NZ_CP116115:1247732-1248073 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References