Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 692913..693171 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PIC92_RS03380 Protein ID WP_000809168.1
Coordinates 692913..693065 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 693114..693171 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS03360 688158..688871 - 714 WP_001102391.1 acidic protein MsyB -
PIC92_RS03365 688897..689301 - 405 WP_000843687.1 DUF2541 family protein -
PIC92_RS03370 689673..691589 + 1917 WP_000516135.1 molecular chaperone DnaK -
PIC92_RS03375 691678..692808 + 1131 WP_001118464.1 molecular chaperone DnaJ -
PIC92_RS03380 692913..693065 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 693114..693171 + 58 - - Antitoxin
PIC92_RS03385 693680..694441 + 762 WP_001274832.1 outer membrane protein OmpK -
PIC92_RS03390 694461..695954 + 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
PIC92_RS03395 696083..697342 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T268059 WP_000809168.1 NZ_CP116115:c693065-692913 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT268059 NZ_CP116115:693114-693171 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References