Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3650339..3650880 Replicon chromosome
Accession NZ_CP116110
Organism Escherichia coli strain DETEC-P80

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag PIC84_RS18055 Protein ID WP_000615983.1
Coordinates 3650602..3650880 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag PIC84_RS18050 Protein ID WP_000729703.1
Coordinates 3650339..3650599 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC84_RS18030 (3646014) 3646014..3646799 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
PIC84_RS18035 (3646771) 3646771..3648483 + 1713 Protein_3527 flagellar biosynthesis protein FlhA -
PIC84_RS18040 (3648707) 3648707..3649204 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
PIC84_RS18045 (3649380) 3649380..3650129 - 750 WP_000056849.1 C40 family peptidase -
PIC84_RS18050 (3650339) 3650339..3650599 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIC84_RS18055 (3650602) 3650602..3650880 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIC84_RS18060 (3651036) 3651036..3651776 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIC84_RS18065 (3651747) 3651747..3652514 - 768 WP_000333380.1 class II glutamine amidotransferase -
PIC84_RS18070 (3652720) 3652720..3653298 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T268034 WP_000615983.1 NZ_CP116110:3650602-3650880 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT268034 WP_000729703.1 NZ_CP116110:3650339-3650599 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References