Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2313864..2315452 | Replicon | chromosome |
Accession | NZ_CP116110 | ||
Organism | Escherichia coli strain DETEC-P80 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | S1ELM3 |
Locus tag | PIC84_RS11430 | Protein ID | WP_001125439.1 |
Coordinates | 2314130..2315452 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | PIC84_RS11425 | Protein ID | WP_001301023.1 |
Coordinates | 2313864..2314130 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PIC84_RS11425 (2313864) | 2313864..2314130 | + | 267 | WP_001301023.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
PIC84_RS11430 (2314130) | 2314130..2315452 | + | 1323 | WP_001125439.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
PIC84_RS11435 (2315764) | 2315764..2315972 | + | 209 | Protein_2235 | AraC family transcriptional regulator | - |
PIC84_RS11440 (2316227) | 2316227..2317453 | + | 1227 | Protein_2236 | fimbria/pilus outer membrane usher protein | - |
PIC84_RS11445 (2317467) | 2317467..2317997 | + | 531 | WP_000876763.1 | fimbrial protein | - |
PIC84_RS11450 (2318010) | 2318010..2318513 | + | 504 | WP_000825452.1 | fimbrial protein | - |
PIC84_RS11455 (2318572) | 2318572..2319486 | + | 915 | WP_000520662.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 2313864..2326673 | 12809 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49275.82 Da Isoelectric Point: 8.2482
>T268031 WP_001125439.1 NZ_CP116110:2314130-2315452 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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