Detailed information of TA system TA026801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 1745756..1747104
• Replicon: chromosome
• Accession: NC_017452
• Organism: Haemophilus influenzae R2846

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: R2846_RS08465
• Protein ID: WP_014551119.1
• Coordinates: 1746073..1747104 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A7H5FVG9
• Locus tag: R2846_RS08460
• Protein ID: WP_005661199.1
• Coordinates: 1745756..1746076 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2846_RS08420	1741174..1741452	+	279	WP_005665661.1	cell division protein FtsB	-
R2846_RS08425	1741452..1742129	+	678	WP_014551114.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
R2846_RS08430	1742126..1742602	+	477	WP_014551115.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
R2846_RS08435	1742912..1743346	-	435	WP_014551116.1	D-tyrosyl-tRNA(Tyr) deacylase	-
R2846_RS08440	1743343..1743783	-	441	WP_014551117.1	FMN-binding protein MioC	-
R2846_RS08445	1743880..1744098	-	219	WP_005650820.1	cell division protein ZapB	-
R2846_RS08450	1744260..1745261	+	1002	WP_014551118.1	class II fructose-bisphosphatase	-
R2846_RS08455	1745460..1745768	+	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
R2846_RS08460	1745756..1746076	+	321	WP_005661199.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
R2846_RS08465	1746073..1747104	+	1032	WP_014551119.1	type II toxin-antitoxin system HipA family toxin	Toxin
R2846_RS08470	1747188..1748846	-	1659	WP_014551120.1	thiol reductant ABC exporter subunit CydC	-
R2846_RS08475	1748839..1750584	-	1746	WP_014551121.1	ABC transporter ATP-binding protein/permease	-
R2846_RS08480	1750637..1750801	-	165	WP_032823763.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39832.44 Da
• Isoelectric Point: 6.5782

>T26801 WP_014551119.1 NC_017452:1746073-1747104 [Haemophilus influenzae R2846]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSLSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T26801 NC_017452:1746073-1747104 [Haemophilus influenzae R2846]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTACATTA
TCTTACAGGCAATAAAAATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTAAGTTATGAGCGTGTTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGTA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACTATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12423.09 Da
• Isoelectric Point: 5.9670

>AT26801 WP_005661199.1 NC_017452:1745756-1746076 [Haemophilus influenzae R2846]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT26801 NC_017452:1745756-1746076 [Haemophilus influenzae R2846]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTACCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A7H5FVG9