Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4646116..4646718 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PIC05_RS22440 Protein ID WP_000897305.1
Coordinates 4646407..4646718 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC05_RS22435 Protein ID WP_000356397.1
Coordinates 4646116..4646406 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS22410 (4642042) 4642042..4642944 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PIC05_RS22415 (4642941) 4642941..4643576 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIC05_RS22420 (4643573) 4643573..4644502 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PIC05_RS22425 (4644832) 4644832..4645074 - 243 WP_001086388.1 protein YiiF -
PIC05_RS22430 (4645293) 4645293..4645511 - 219 WP_001295676.1 CopG family transcriptional regulator -
PIC05_RS22435 (4646116) 4646116..4646406 - 291 WP_000356397.1 NadS family protein Antitoxin
PIC05_RS22440 (4646407) 4646407..4646718 - 312 WP_000897305.1 hypothetical protein Toxin
PIC05_RS22445 (4646947) 4646947..4647855 + 909 WP_001162704.1 alpha/beta hydrolase -
PIC05_RS22450 (4647919) 4647919..4648860 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIC05_RS22455 (4648905) 4648905..4649342 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIC05_RS22460 (4649339) 4649339..4650211 - 873 WP_000920762.1 virulence factor BrkB family protein -
PIC05_RS22465 (4650205) 4650205..4650804 - 600 WP_001315111.1 glucose-1-phosphatase -
PIC05_RS22470 (4650903) 4650903..4651688 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T268001 WP_000897305.1 NZ_CP116106:c4646718-4646407 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT268001 WP_000356397.1 NZ_CP116106:c4646406-4646116 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References