Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 590996..591795 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag PIC05_RS02900 Protein ID WP_000347267.1
Coordinates 590996..591460 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIC05_RS02905 Protein ID WP_001307405.1
Coordinates 591460..591795 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS02870 (585997) 585997..586431 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PIC05_RS02875 (586449) 586449..587327 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC05_RS02880 (587317) 587317..588096 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC05_RS02885 (588107) 588107..588580 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC05_RS02890 (588603) 588603..589883 - 1281 WP_000681947.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC05_RS02895 (590132) 590132..590941 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
PIC05_RS02900 (590996) 590996..591460 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC05_RS02905 (591460) 591460..591795 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC05_RS02910 (591944) 591944..593515 - 1572 WP_001273741.1 galactarate dehydratase -
PIC05_RS02915 (593890) 593890..595224 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PIC05_RS02920 (595240) 595240..596010 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T267986 WP_000347267.1 NZ_CP116106:c591460-590996 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267986 WP_001307405.1 NZ_CP116106:c591795-591460 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References