Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3970745..3971438 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIB67_RS19340 Protein ID WP_000415584.1
Coordinates 3971142..3971438 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIB67_RS19335 Protein ID WP_000650107.1
Coordinates 3970745..3971140 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS19325 (3966609) 3966609..3968867 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
PIB67_RS19330 (3969005) 3969005..3970612 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PIB67_RS19335 (3970745) 3970745..3971140 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIB67_RS19340 (3971142) 3971142..3971438 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIB67_RS19345 (3971643) 3971643..3972125 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PIB67_RS19350 (3972178) 3972178..3972570 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIB67_RS19355 (3972722) 3972722..3973381 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIB67_RS19360 (3973378) 3973378..3974727 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIB67_RS19365 (3974773) 3974773..3975105 - 333 WP_000917685.1 DUF2645 family protein -
PIB67_RS19370 (3975424) 3975424..3976005 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PIB67_RS19375 (3976036) 3976036..3976350 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3962282..3971438 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T267977 WP_000415584.1 NZ_CP116103:c3971438-3971142 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT267977 WP_000650107.1 NZ_CP116103:c3971140-3970745 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References