Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2839718..2840220 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PIB67_RS14130 Protein ID WP_000767822.1
Coordinates 2839718..2839972 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIB67_RS14135 Protein ID WP_001259255.1
Coordinates 2839969..2840220 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS14110 2836211..2837569 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
PIB67_RS14115 2837559..2837621 - 63 WP_010723108.1 membrane protein YoeI -
PIB67_RS14120 2837836..2838765 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIB67_RS14125 2838811..2839635 - 825 WP_000754737.1 SDR family oxidoreductase -
PIB67_RS14130 2839718..2839972 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIB67_RS14135 2839969..2840220 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIB67_RS14140 2840503..2840553 + 51 WP_001364200.1 his operon leader peptide -
PIB67_RS14145 2840699..2841598 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
PIB67_RS14150 2841604..2842908 + 1305 WP_001445483.1 histidinol dehydrogenase -
PIB67_RS14155 2842905..2843975 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
PIB67_RS14160 2843975..2845042 + 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T267974 WP_000767822.1 NZ_CP116103:c2839972-2839718 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT267974 WP_001259255.1 NZ_CP116103:c2840220-2839969 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References