Detailed information of TA system TA026797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 812420..813059
• Replicon: chromosome
• Accession: NC_017452
• Organism: Haemophilus influenzae R2846

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q4QJX7
• Locus tag: R2846_RS03935
• Protein ID: WP_005650215.1
• Coordinates: 812420..812725 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: R2846_RS03940
• Protein ID: WP_005650217.1
• Coordinates: 812736..813059 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2846_RS03915	807851..809890	-	2040	WP_005687320.1	excinuclease ABC subunit B	-
R2846_RS03925	810504..811472	-	969	WP_014550701.1	zinc transporter permease subunit ZevB	-
R2846_RS03930	811475..812095	-	621	WP_014550702.1	zinc transporter binding subunit ZevA	-
R2846_RS03935	812420..812725	+	306	WP_005650215.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
R2846_RS03940	812736..813059	+	324	WP_005650217.1	HigA family addiction module antidote protein	Antitoxin
R2846_RS03945	813223..814893	+	1671	WP_005663485.1	energy-dependent translational throttle protein EttA	-
R2846_RS03950	814955..815296	+	342	WP_005652996.1	SirB2 family protein	-
R2846_RS03955	815301..817271	+	1971	WP_014550704.1	tRNA(Met) cytidine acetyltransferase TmcA	-
R2846_RS09180	817268..817441	+	174	WP_005652999.1	DUF5363 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-99)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (4-82)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12301.93 Da
• Isoelectric Point: 9.0853

>T26797 WP_005650215.1 NC_017452:812420-812725 [Haemophilus influenzae R2846]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Nucleotide

• Length: 306 bp

>T26797 NC_017452:812420-812725 [Haemophilus influenzae R2846]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12347.17 Da
• Isoelectric Point: 6.8804

>AT26797 WP_005650217.1 NC_017452:812736-813059 [Haemophilus influenzae R2846]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Nucleotide

• Length: 324 bp

>AT26797 NC_017452:812736-813059 [Haemophilus influenzae R2846]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Structures

Toxin

• AlphaFold DB: A0A806EC70