Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2272203..2272765 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag PIB67_RS11190 Protein ID WP_000605675.1
Coordinates 2272487..2272765 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PIB67_RS11185 Protein ID WP_000781370.1
Coordinates 2272203..2272487 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS11170 (2267384) 2267384..2270431 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
PIB67_RS11175 (2270444) 2270444..2271328 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
PIB67_RS11180 (2271321) 2271321..2271974 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
PIB67_RS11185 (2272203) 2272203..2272487 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PIB67_RS11190 (2272487) 2272487..2272765 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIB67_RS11195 (2272951) 2272951..2273961 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
PIB67_RS11200 (2274095) 2274095..2275792 - 1698 WP_000433460.1 malate dehydrogenase -
PIB67_RS11205 (2275949) 2275949..2276086 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
PIB67_RS11210 (2276188) 2276188..2276403 - 216 WP_000495766.1 biofilm-dependent modulation protein -
PIB67_RS11215 (2276748) 2276748..2277179 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T267969 WP_000605675.1 NZ_CP116103:c2272765-2272487 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT267969 WP_000781370.1 NZ_CP116103:c2272487-2272203 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References