Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3664895..3665622 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PIC52_RS17800 Protein ID WP_000550189.1
Coordinates 3664895..3665209 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC52_RS17805 Protein ID WP_000560266.1
Coordinates 3665206..3665622 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS17780 (3661052) 3661052..3662038 - 987 WP_001385498.1 Gfo/Idh/MocA family oxidoreductase -
PIC52_RS17785 (3662117) 3662117..3662809 - 693 WP_000946651.1 vancomycin high temperature exclusion protein -
PIC52_RS17790 (3662886) 3662886..3663389 - 504 WP_001295542.1 M48 family metallopeptidase -
PIC52_RS17795 (3663474) 3663474..3664610 + 1137 WP_001606198.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PIC52_RS17800 (3664895) 3664895..3665209 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PIC52_RS17805 (3665206) 3665206..3665622 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PIC52_RS17810 (3665667) 3665667..3667685 - 2019 WP_001606197.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PIC52_RS17815 (3667911) 3667911..3670262 - 2352 WP_001606195.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T267947 WP_000550189.1 NZ_CP116100:3664895-3665209 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT267947 WP_000560266.1 NZ_CP116100:3665206-3665622 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References