Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3622935..3623734 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PIC52_RS17575 Protein ID WP_000347251.1
Coordinates 3622935..3623399 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PIC52_RS17580 Protein ID WP_001296435.1
Coordinates 3623399..3623734 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS17545 (3617936) 3617936..3618370 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PIC52_RS17550 (3618388) 3618388..3619266 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC52_RS17555 (3619256) 3619256..3620035 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC52_RS17560 (3620046) 3620046..3620519 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC52_RS17565 (3620542) 3620542..3621822 - 1281 WP_001606210.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC52_RS17570 (3622071) 3622071..3622880 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIC52_RS17575 (3622935) 3622935..3623399 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC52_RS17580 (3623399) 3623399..3623734 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC52_RS17585 (3623883) 3623883..3625454 - 1572 WP_001273763.1 galactarate dehydratase -
PIC52_RS17590 (3625829) 3625829..3627163 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
PIC52_RS17595 (3627179) 3627179..3627949 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T267946 WP_000347251.1 NZ_CP116100:c3623399-3622935 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT267946 WP_001296435.1 NZ_CP116100:c3623734-3623399 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References