Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2802733..2803335 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PIC52_RS13550 Protein ID WP_024193748.1
Coordinates 2803024..2803335 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC52_RS13545 Protein ID WP_000356397.1
Coordinates 2802733..2803023 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS13515 (2797890) 2797890..2798819 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PIC52_RS13520 (2799149) 2799149..2799391 - 243 WP_001523574.1 CopG family transcriptional regulator -
PIC52_RS13525 (2799681) 2799681..2800529 + 849 WP_001038651.1 hypothetical protein -
PIC52_RS13530 (2800554) 2800554..2801294 + 741 WP_000608806.1 hypothetical protein -
PIC52_RS13535 (2801479) 2801479..2801697 - 219 WP_001251293.1 CopG family transcriptional regulator -
PIC52_RS13540 (2802096) 2802096..2802374 - 279 WP_001296612.1 hypothetical protein -
PIC52_RS13545 (2802733) 2802733..2803023 - 291 WP_000356397.1 NadS family protein Antitoxin
PIC52_RS13550 (2803024) 2803024..2803335 - 312 WP_024193748.1 hypothetical protein Toxin
PIC52_RS13555 (2803564) 2803564..2804472 + 909 WP_001385591.1 alpha/beta hydrolase -
PIC52_RS13560 (2804536) 2804536..2805477 - 942 WP_001606560.1 fatty acid biosynthesis protein FabY -
PIC52_RS13565 (2805522) 2805522..2805959 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIC52_RS13570 (2805956) 2805956..2806828 - 873 WP_000920763.1 virulence factor BrkB family protein -
PIC52_RS13575 (2806822) 2806822..2807421 - 600 WP_001296610.1 glucose-1-phosphatase -
PIC52_RS13580 (2807520) 2807520..2808305 - 786 WP_001606559.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12302.33 Da        Isoelectric Point: 10.0233

>T267941 WP_024193748.1 NZ_CP116100:c2803335-2803024 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGRIRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT267941 WP_000356397.1 NZ_CP116100:c2803023-2802733 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References