Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1868629..1869323 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PIC52_RS09225 Protein ID WP_001263500.1
Coordinates 1868629..1869027 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PIC52_RS09230 Protein ID WP_000554758.1
Coordinates 1869030..1869323 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS09200 (1863995) 1863995..1864453 - 459 WP_001291991.1 xanthine phosphoribosyltransferase -
PIC52_RS09205 (1864714) 1864714..1866171 + 1458 WP_001293022.1 cytosol nonspecific dipeptidase -
PIC52_RS09210 (1866227) 1866227..1866841 - 615 WP_001606887.1 peptide chain release factor H -
PIC52_RS09215 (1866838) 1866838..1867977 - 1140 WP_001606885.1 RNA ligase RtcB family protein -
PIC52_RS09220 (1868167) 1868167..1868619 - 453 WP_071589393.1 GNAT family N-acetyltransferase -
PIC52_RS09225 (1868629) 1868629..1869027 - 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PIC52_RS09230 (1869030) 1869030..1869323 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PIC52_RS09235 (1869375) 1869375..1870430 - 1056 WP_001226168.1 DNA polymerase IV -
PIC52_RS09240 (1870501) 1870501..1871286 - 786 WP_000207551.1 putative lateral flagellar export/assembly protein LafU -
PIC52_RS09245 (1871258) 1871258..1872970 + 1713 Protein_1815 flagellar biosynthesis protein FlhA -
PIC52_RS09250 (1873086) 1873086..1873583 - 498 WP_001606851.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T267937 WP_001263500.1 NZ_CP116100:c1869027-1868629 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT267937 WP_000554758.1 NZ_CP116100:c1869323-1869030 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References