Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 1847475..1848823 Replicon chromosome
Accession NC_017451
Organism Haemophilus influenzae R2866

Toxin (Protein)


Gene name HipT Uniprot ID A0A806EDV8
Locus tag R2866_RS09090 Protein ID WP_020910208.1
Coordinates 1847792..1848823 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A806DF96
Locus tag R2866_RS09085 Protein ID WP_020910207.1
Coordinates 1847475..1847795 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2866_RS09045 1842889..1843167 + 279 WP_005661211.1 cell division protein FtsB -
R2866_RS09050 1843167..1843844 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
R2866_RS09055 1843841..1844317 + 477 WP_005650817.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
R2866_RS09060 1844630..1845064 - 435 WP_005650818.1 D-tyrosyl-tRNA(Tyr) deacylase -
R2866_RS09065 1845061..1845501 - 441 WP_020910205.1 FMN-binding protein MioC -
R2866_RS09070 1845598..1845816 - 219 WP_005650820.1 cell division protein ZapB -
R2866_RS09075 1845978..1846979 + 1002 WP_020910206.1 class II fructose-bisphosphatase -
R2866_RS09080 1847179..1847487 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
R2866_RS09085 1847475..1847795 + 321 WP_020910207.1 type II toxin-antitoxin system HipA family toxin Antitoxin
R2866_RS09090 1847792..1848823 + 1032 WP_020910208.1 type II toxin-antitoxin system HipA family toxin Toxin
R2866_RS09095 1848906..1850564 - 1659 WP_020910209.1 thiol reductant ABC exporter subunit CydC -
R2866_RS09100 1850557..1852302 - 1746 WP_020910210.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39886.46 Da        Isoelectric Point: 6.2886

>T26793 WP_020910208.1 NC_017451:1847792-1848823 [Haemophilus influenzae R2866]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVPFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T26793 NC_017451:1847792-1848823 [Haemophilus influenzae R2866]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTCCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTAAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATAGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12438.06 Da        Isoelectric Point: 5.8850

>AT26793 WP_020910207.1 NC_017451:1847475-1847795 [Haemophilus influenzae R2866]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT26793 NC_017451:1847475-1847795 [Haemophilus influenzae R2866]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EDV8

Antitoxin

Source ID Structure
AlphaFold DB A0A806DF96

References