Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 157744..158380 Replicon chromosome
Accession NZ_CP116100
Organism Escherichia coli strain DETEC-P881

Toxin (Protein)


Gene name higB Uniprot ID A0A7L6CLM4
Locus tag PIC52_RS00805 Protein ID WP_001607612.1
Coordinates 158051..158380 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC52_RS00800 Protein ID WP_001553123.1
Coordinates 157744..158046 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC52_RS00790 (154395) 154395..155657 + 1263 WP_001607616.1 integrase arm-type DNA-binding domain-containing protein -
PIC52_RS00795 (156352) 156352..157236 - 885 WP_001607614.1 integrase domain-containing protein -
PIC52_RS00800 (157744) 157744..158046 - 303 WP_001553123.1 XRE family transcriptional regulator Antitoxin
PIC52_RS00805 (158051) 158051..158380 - 330 WP_001607612.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIC52_RS00810 (158901) 158901..159122 - 222 WP_001607610.1 helix-turn-helix transcriptional regulator -
PIC52_RS00815 (159119) 159119..159586 - 468 WP_001607609.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 134081..188320 54239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12529.28 Da        Isoelectric Point: 8.9627

>T267928 WP_001607612.1 NZ_CP116100:c158380-158051 [Escherichia coli]
MFDHWFTSLNDTDRASVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRIQSRGDPIRAFFAFDPARTGIVLCAGNKV
GNEKRFYDEMLPIADREFTNWLNTLKEKE

Download         Length: 330 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11084.82 Da        Isoelectric Point: 5.1786

>AT267928 WP_001553123.1 NZ_CP116100:c158046-157744 [Escherichia coli]
MGRTLEQLIADEKPEVVDEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6CLM4

Antitoxin

Source ID Structure

References