Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3992337..3993030 Replicon chromosome
Accession NZ_CP116094
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIC78_RS19290 Protein ID WP_000415584.1
Coordinates 3992734..3993030 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIC78_RS19285 Protein ID WP_000650107.1
Coordinates 3992337..3992732 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS19270 (3989273) 3989273..3990274 - 1002 Protein_3761 ABC transporter substrate-binding protein -
PIC78_RS19275 (3990336) 3990336..3991556 + 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
PIC78_RS19280 (3991485) 3991485..3992204 - 720 Protein_3763 ABC transporter substrate-binding protein -
PIC78_RS19285 (3992337) 3992337..3992732 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIC78_RS19290 (3992734) 3992734..3993030 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIC78_RS19295 (3993235) 3993235..3993717 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PIC78_RS19300 (3993770) 3993770..3994162 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIC78_RS19305 (3994314) 3994314..3994973 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIC78_RS19310 (3994970) 3994970..3996319 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIC78_RS19315 (3996365) 3996365..3996697 - 333 WP_000917685.1 DUF2645 family protein -
PIC78_RS19320 (3997016) 3997016..3997597 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PIC78_RS19325 (3997628) 3997628..3997942 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3990336..3991556 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T267912 WP_000415584.1 NZ_CP116094:c3993030-3992734 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT267912 WP_000650107.1 NZ_CP116094:c3992732-3992337 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References