Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2205013..2205651 Replicon chromosome
Accession NZ_CP116094
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag PIC78_RS10840 Protein ID WP_001447010.1
Coordinates 2205013..2205189 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIC78_RS10845 Protein ID WP_001270286.1
Coordinates 2205235..2205651 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS10820 (2200632) 2200632..2201807 - 1176 WP_001236265.1 BenE family transporter YdcO -
PIC78_RS10825 (2201899) 2201899..2202435 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PIC78_RS10830 (2202508) 2202508..2204469 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIC78_RS10835 (2204561) 2204561..2204791 - 231 WP_000494244.1 YncJ family protein -
PIC78_RS10840 (2205013) 2205013..2205189 + 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIC78_RS10845 (2205235) 2205235..2205651 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIC78_RS10850 (2205730) 2205730..2207136 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PIC78_RS10855 (2207381) 2207381..2208526 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PIC78_RS10860 (2208544) 2208544..2209557 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PIC78_RS10865 (2209558) 2209558..2210499 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2199444..2200592 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T267901 WP_001447010.1 NZ_CP116094:2205013-2205189 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT267901 WP_001270286.1 NZ_CP116094:2205235-2205651 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References