Detailed information of TA system TA026790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 853885..854524
• Replicon: chromosome
• Accession: NC_017451
• Organism: Haemophilus influenzae R2866

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q4QJX7
• Locus tag: R2866_RS04210
• Protein ID: WP_005650215.1
• Coordinates: 853885..854190 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: R2866_RS04215
• Protein ID: WP_005650217.1
• Coordinates: 854201..854524 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2866_RS04190	849315..851354	-	2040	WP_005646675.1	excinuclease ABC subunit B	-
R2866_RS04200	851969..852937	-	969	WP_005666730.1	zinc transporter permease subunit ZevB	-
R2866_RS04205	852940..853560	-	621	WP_005666732.1	zinc transporter binding subunit ZevA	-
R2866_RS04210	853885..854190	+	306	WP_005650215.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
R2866_RS04215	854201..854524	+	324	WP_005650217.1	HigA family addiction module antidote protein	Antitoxin
R2866_RS04220	854687..856357	+	1671	WP_005650218.1	energy-dependent translational throttle protein EttA	-
R2866_RS04225	856419..856760	+	342	WP_005666735.1	SirB2 family protein	-
R2866_RS04230	856765..858735	+	1971	WP_005666737.1	tRNA(Met) cytidine acetyltransferase TmcA	-
R2866_RS09955	858732..858905	+	174	WP_005637028.1	DUF5363 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-99)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (4-82)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12301.93 Da
• Isoelectric Point: 9.0853

>T26790 WP_005650215.1 NC_017451:853885-854190 [Haemophilus influenzae R2866]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Nucleotide

• Length: 306 bp

>T26790 NC_017451:853885-854190 [Haemophilus influenzae R2866]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12347.17 Da
• Isoelectric Point: 6.8804

>AT26790 WP_005650217.1 NC_017451:854201-854524 [Haemophilus influenzae R2866]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Nucleotide

• Length: 324 bp

>AT26790 NC_017451:854201-854524 [Haemophilus influenzae R2866]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACACTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Structures

Toxin

• AlphaFold DB: A0A806EC70