Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 842434..842975 Replicon chromosome
Accession NZ_CP116094
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag PIC78_RS04025 Protein ID WP_000615983.1
Coordinates 842434..842712 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag PIC78_RS04030 Protein ID WP_000729703.1
Coordinates 842715..842975 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS04010 (840016) 840016..840594 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PIC78_RS04015 (840800) 840800..841567 + 768 WP_000333380.1 class II glutamine amidotransferase -
PIC78_RS04020 (841538) 841538..842278 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIC78_RS04025 (842434) 842434..842712 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIC78_RS04030 (842715) 842715..842975 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIC78_RS04035 (843185) 843185..843934 + 750 WP_000056849.1 C40 family peptidase -
PIC78_RS04040 (844110) 844110..844607 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
PIC78_RS04045 (844831) 844831..846543 - 1713 Protein_781 flagellar biosynthesis protein FlhA -
PIC78_RS04050 (846515) 846515..847300 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 833649..867460 33811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T267898 WP_000615983.1 NZ_CP116094:c842712-842434 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT267898 WP_000729703.1 NZ_CP116094:c842975-842715 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References