Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3351232..3351834 Replicon chromosome
Accession NZ_CP116088
Organism Escherichia coli strain DETEC-S565

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PIC22_RS16520 Protein ID WP_000897305.1
Coordinates 3351232..3351543 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC22_RS16525 Protein ID WP_000356397.1
Coordinates 3351544..3351834 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC22_RS16490 (3346262) 3346262..3347047 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
PIC22_RS16495 (3347146) 3347146..3347745 + 600 WP_001295269.1 glucose-1-phosphatase -
PIC22_RS16500 (3347739) 3347739..3348611 + 873 WP_000920762.1 virulence factor BrkB family protein -
PIC22_RS16505 (3348608) 3348608..3349045 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIC22_RS16510 (3349090) 3349090..3350031 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIC22_RS16515 (3350095) 3350095..3351003 - 909 WP_001162704.1 alpha/beta hydrolase -
PIC22_RS16520 (3351232) 3351232..3351543 + 312 WP_000897305.1 hypothetical protein Toxin
PIC22_RS16525 (3351544) 3351544..3351834 + 291 WP_000356397.1 NadS family protein Antitoxin
PIC22_RS16530 (3352420) 3352420..3352638 + 219 WP_001295676.1 CopG family transcriptional regulator -
PIC22_RS16535 (3352857) 3352857..3353099 + 243 WP_001087409.1 protein YiiF -
PIC22_RS16540 (3353429) 3353429..3354358 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PIC22_RS16545 (3354355) 3354355..3354990 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIC22_RS16550 (3354987) 3354987..3355889 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T267878 WP_000897305.1 NZ_CP116088:3351232-3351543 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT267878 WP_000356397.1 NZ_CP116088:3351544-3351834 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References