Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1932148..1932650 Replicon chromosome
Accession NZ_CP116085
Organism Escherichia coli strain DETEC-S566

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PIC95_RS09275 Protein ID WP_000767822.1
Coordinates 1932396..1932650 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIC95_RS09270 Protein ID WP_001259255.1
Coordinates 1932148..1932399 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC95_RS09245 (1927326) 1927326..1928393 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PIC95_RS09250 (1928393) 1928393..1929463 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
PIC95_RS09255 (1929460) 1929460..1930764 - 1305 WP_001546022.1 histidinol dehydrogenase -
PIC95_RS09260 (1930770) 1930770..1931669 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
PIC95_RS09265 (1931815) 1931815..1931865 - 51 WP_001364200.1 his operon leader peptide -
PIC95_RS09270 (1932148) 1932148..1932399 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIC95_RS09275 (1932396) 1932396..1932650 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIC95_RS09280 (1932733) 1932733..1933557 + 825 WP_000754737.1 SDR family oxidoreductase -
PIC95_RS09285 (1933603) 1933603..1934532 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIC95_RS09290 (1934747) 1934747..1934809 + 63 WP_010723108.1 membrane protein YoeI -
PIC95_RS09295 (1934799) 1934799..1936157 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T267849 WP_000767822.1 NZ_CP116085:1932396-1932650 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT267849 WP_001259255.1 NZ_CP116085:1932148-1932399 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References