Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 707663..708356 Replicon chromosome
Accession NZ_CP116085
Organism Escherichia coli strain DETEC-S566

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIC95_RS03490 Protein ID WP_000415584.1
Coordinates 707663..707959 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIC95_RS03495 Protein ID WP_000650107.1
Coordinates 707961..708356 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC95_RS03455 (702751) 702751..703065 - 315 WP_000958598.1 putative quinol monooxygenase -
PIC95_RS03460 (703096) 703096..703677 - 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
PIC95_RS03465 (703996) 703996..704328 + 333 WP_000917684.1 DUF2645 family protein -
PIC95_RS03470 (704374) 704374..705723 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PIC95_RS03475 (705720) 705720..706379 - 660 WP_001221510.1 quorum sensing response regulator transcription factor QseB -
PIC95_RS03480 (706531) 706531..706923 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIC95_RS03485 (706976) 706976..707458 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PIC95_RS03490 (707663) 707663..707959 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIC95_RS03495 (707961) 707961..708356 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIC95_RS03500 (708489) 708489..710096 + 1608 WP_001735743.1 ABC transporter substrate-binding protein -
PIC95_RS03505 (710234) 710234..712492 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T267846 WP_000415584.1 NZ_CP116085:707663-707959 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp


Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT267846 WP_000650107.1 NZ_CP116085:707961-708356 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References