267811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 633275..634074 Replicon chromosome
Accession NZ_CP116074
Organism Escherichia coli strain DETEC-S586

Toxin (Protein)


Gene name yhaV Uniprot ID B7NDB6
Locus tag PIC49_RS03065 Protein ID WP_000347269.1
Coordinates 633275..633739 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag PIC49_RS03070 Protein ID WP_001309780.1
Coordinates 633739..634074 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC49_RS03035 (628276) 628276..628710 - 435 WP_000948818.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PIC49_RS03040 (628728) 628728..629606 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC49_RS03045 (629596) 629596..630375 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC49_RS03050 (630386) 630386..630859 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC49_RS03055 (630882) 630882..632162 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC49_RS03060 (632411) 632411..633220 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
PIC49_RS03065 (633275) 633275..633739 - 465 WP_000347269.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC49_RS03070 (633739) 633739..634074 - 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC49_RS03075 (634223) 634223..635794 - 1572 WP_001273738.1 galactarate dehydratase -
PIC49_RS03080 (636169) 636169..637503 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
PIC49_RS03085 (637519) 637519..638289 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T267811 WP_000347269.1 NZ_CP116074:c633739-633275 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT267811 WP_001309780.1 NZ_CP116074:c634074-633739 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IY86

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References