Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5012570..5013172 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PIC30_RS24785 Protein ID WP_000897302.1
Coordinates 5012861..5013172 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PIC30_RS24780 Protein ID WP_000356397.1
Coordinates 5012570..5012860 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS24755 (5008643) 5008643..5009545 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PIC30_RS24760 (5009542) 5009542..5010177 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PIC30_RS24765 (5010174) 5010174..5011103 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
PIC30_RS24770 (5011319) 5011319..5011537 - 219 WP_001314326.1 CopG family transcriptional regulator -
PIC30_RS24775 (5011933) 5011933..5012211 - 279 WP_001296612.1 hypothetical protein -
PIC30_RS24780 (5012570) 5012570..5012860 - 291 WP_000356397.1 NadS family protein Antitoxin
PIC30_RS24785 (5012861) 5012861..5013172 - 312 WP_000897302.1 hypothetical protein Toxin
PIC30_RS24790 (5013401) 5013401..5014309 + 909 WP_001331553.1 alpha/beta hydrolase -
PIC30_RS24795 (5014373) 5014373..5015314 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PIC30_RS24800 (5015359) 5015359..5015796 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PIC30_RS24805 (5015793) 5015793..5016665 - 873 WP_000920762.1 virulence factor BrkB family protein -
PIC30_RS24810 (5016659) 5016659..5017258 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T267800 WP_000897302.1 NZ_CP116071:c5013172-5012861 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT267800 WP_000356397.1 NZ_CP116071:c5012860-5012570 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References