Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4256041..4256299 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PIC30_RS21185 Protein ID WP_000809168.1
Coordinates 4256147..4256299 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4256041..4256098 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS21170 4251873..4253132 - 1260 WP_271287397.1 cytoplasmic protein -
PIC30_RS21175 4253261..4254754 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
PIC30_RS21180 4254774..4255535 - 762 WP_001274823.1 outer membrane protein OmpK -
- 4256041..4256098 - 58 - - Antitoxin
PIC30_RS21185 4256147..4256299 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PIC30_RS21190 4256404..4257534 - 1131 WP_001118464.1 molecular chaperone DnaJ -
PIC30_RS21195 4257623..4259539 - 1917 WP_000516135.1 molecular chaperone DnaK -
PIC30_RS21200 4259911..4260315 + 405 WP_000843687.1 DUF2541 family protein -
PIC30_RS21205 4260341..4261054 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T267796 WP_000809168.1 NZ_CP116071:4256147-4256299 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT267796 NZ_CP116071:c4256098-4256041 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References