Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1876675..1877177 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PIC30_RS09055 Protein ID WP_000767822.1
Coordinates 1876923..1877177 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PIC30_RS09050 Protein ID WP_001259255.1
Coordinates 1876675..1876926 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS09025 (1871853) 1871853..1872920 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PIC30_RS09030 (1872920) 1872920..1873990 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
PIC30_RS09035 (1873987) 1873987..1875291 - 1305 WP_001297912.1 histidinol dehydrogenase -
PIC30_RS09040 (1875297) 1875297..1876196 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
PIC30_RS09045 (1876342) 1876342..1876392 - 51 WP_001364200.1 his operon leader peptide -
PIC30_RS09050 (1876675) 1876675..1876926 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PIC30_RS09055 (1876923) 1876923..1877177 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PIC30_RS09060 (1877260) 1877260..1878084 + 825 WP_000754733.1 SDR family oxidoreductase -
PIC30_RS09065 (1878130) 1878130..1879059 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PIC30_RS09070 (1879274) 1879274..1879336 + 63 WP_010723108.1 membrane protein YoeI -
PIC30_RS09075 (1879326) 1879326..1880684 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T267779 WP_000767822.1 NZ_CP116071:1876923-1877177 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT267779 WP_001259255.1 NZ_CP116071:1876675-1876926 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References