Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3602547..3603149 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PID00_RS18010 Protein ID WP_096122058.1
Coordinates 3602547..3602858 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PID00_RS18015 Protein ID WP_000356397.1
Coordinates 3602859..3603149 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS17985 (3598461) 3598461..3599060 + 600 WP_001296610.1 glucose-1-phosphatase -
PID00_RS17990 (3599054) 3599054..3599926 + 873 WP_000920763.1 virulence factor BrkB family protein -
PID00_RS17995 (3599923) 3599923..3600360 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PID00_RS18000 (3600405) 3600405..3601346 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PID00_RS18005 (3601410) 3601410..3602318 - 909 WP_001385591.1 alpha/beta hydrolase -
PID00_RS18010 (3602547) 3602547..3602858 + 312 WP_096122058.1 toxin HigB-2 Toxin
PID00_RS18015 (3602859) 3602859..3603149 + 291 WP_000356397.1 NadS family protein Antitoxin
PID00_RS18020 (3603754) 3603754..3603972 + 219 WP_001298592.1 CopG family transcriptional regulator -
PID00_RS18025 (3604187) 3604187..3605116 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
PID00_RS18030 (3605113) 3605113..3605748 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PID00_RS18035 (3605745) 3605745..3606647 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12274.27 Da        Isoelectric Point: 9.7791

>T267764 WP_096122058.1 NZ_CP116067:3602547-3602858 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGRLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLQLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT267764 WP_000356397.1 NZ_CP116067:3602859-3603149 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References