Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2762412..2763211 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PID00_RS13930 Protein ID WP_000347251.1
Coordinates 2762747..2763211 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PID00_RS13925 Protein ID WP_001307405.1
Coordinates 2762412..2762747 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS13910 (2758197) 2758197..2758967 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
PID00_RS13915 (2758983) 2758983..2760317 - 1335 WP_000599654.1 galactarate/glucarate/glycerate transporter GarP -
PID00_RS13920 (2760692) 2760692..2762263 + 1572 WP_001559982.1 galactarate dehydratase -
PID00_RS13925 (2762412) 2762412..2762747 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PID00_RS13930 (2762747) 2762747..2763211 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PID00_RS13935 (2763266) 2763266..2764075 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PID00_RS13940 (2764324) 2764324..2765604 + 1281 WP_001562147.1 tagatose-bisphosphate aldolase subunit KbaZ -
PID00_RS13945 (2765627) 2765627..2766100 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PID00_RS13950 (2766111) 2766111..2766890 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PID00_RS13955 (2766880) 2766880..2767758 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PID00_RS13960 (2767776) 2767776..2768210 + 435 WP_000948823.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2754716..2763211 8495


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T267760 WP_000347251.1 NZ_CP116067:2762747-2763211 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267760 WP_001307405.1 NZ_CP116067:2762412-2762747 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References