Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3986444..3986985 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag PIH14_RS19250 Protein ID WP_000615983.1
Coordinates 3986444..3986722 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag PIH14_RS19255 Protein ID WP_000729703.1
Coordinates 3986725..3986985 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS19235 (3984026) 3984026..3984604 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PIH14_RS19240 (3984810) 3984810..3985577 + 768 WP_000333380.1 class II glutamine amidotransferase -
PIH14_RS19245 (3985548) 3985548..3986288 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PIH14_RS19250 (3986444) 3986444..3986722 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PIH14_RS19255 (3986725) 3986725..3986985 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PIH14_RS19260 (3987195) 3987195..3987944 + 750 WP_220423535.1 C40 family peptidase -
PIH14_RS19265 (3988120) 3988120..3988617 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
PIH14_RS19270 (3988841) 3988841..3990553 - 1713 Protein_3754 flagellar biosynthesis protein FlhA -
PIH14_RS19275 (3990525) 3990525..3991310 + 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T267740 WP_000615983.1 NZ_CP116046:c3986722-3986444 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT267740 WP_000729703.1 NZ_CP116046:c3986985-3986725 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References