Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2138925..2139618 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PIH14_RS10430 Protein ID WP_000415584.1
Coordinates 2139322..2139618 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PIH14_RS10425 Protein ID WP_000650107.1
Coordinates 2138925..2139320 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS10415 (2134789) 2134789..2137047 - 2259 WP_088213288.1 DNA topoisomerase IV subunit A -
PIH14_RS10420 (2137185) 2137185..2138792 - 1608 WP_088213289.1 ABC transporter substrate-binding protein -
PIH14_RS10425 (2138925) 2138925..2139320 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PIH14_RS10430 (2139322) 2139322..2139618 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PIH14_RS10435 (2139823) 2139823..2140305 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PIH14_RS10440 (2140358) 2140358..2140750 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PIH14_RS10445 (2140902) 2140902..2141561 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PIH14_RS10450 (2141558) 2141558..2142907 + 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
PIH14_RS10455 (2142953) 2142953..2143285 - 333 WP_000917684.1 DUF2645 family protein -
PIH14_RS10460 (2143604) 2143604..2144185 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PIH14_RS10465 (2144216) 2144216..2144530 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T267734 WP_000415584.1 NZ_CP116046:c2139618-2139322 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT267734 WP_000650107.1 NZ_CP116046:c2139320-2138925 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References