Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1004164..1004752 Replicon chromosome
Accession NC_017382
Organism Helicobacter pylori 51

Toxin (Protein)


Gene name TfiT Uniprot ID M3P300
Locus tag KHP_RS04815 Protein ID WP_000921941.1
Coordinates 1004164..1004445 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID T5CU17
Locus tag KHP_RS04820 Protein ID WP_000065285.1
Coordinates 1004438..1004752 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHP_RS04805 1000361..1002109 + 1749 WP_001141028.1 DUF262 domain-containing protein -
KHP_RS04810 1002110..1003837 + 1728 WP_001208214.1 type IV secretory system conjugative DNA transfer family protein -
KHP_RS04815 1004164..1004445 - 282 WP_000921941.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
KHP_RS04820 1004438..1004752 - 315 WP_000065285.1 hypothetical protein Antitoxin
KHP_RS08030 1005048..1006959 + 1912 Protein_924 relaxase/mobilization nuclease domain-containing protein -
KHP_RS04835 1006984..1008147 - 1164 WP_000751571.1 hypothetical protein -
KHP_RS04840 1008179..1008460 - 282 WP_000394649.1 hypothetical protein -
KHP_RS04845 1008545..1009201 - 657 WP_000587411.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10891.80 Da        Isoelectric Point: 9.5726

>T26771 WP_000921941.1 NC_017382:c1004445-1004164 [Helicobacter pylori 51]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T26771 NC_017382:c1004445-1004164 [Helicobacter pylori 51]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGTGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12121.58 Da        Isoelectric Point: 5.2066

>AT26771 WP_000065285.1 NC_017382:c1004752-1004438 [Helicobacter pylori 51]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT26771 NC_017382:c1004752-1004438 [Helicobacter pylori 51]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAACAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTGAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M3P300

Antitoxin

Source ID Structure
AlphaFold DB T5CU17

References