Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1066632..1067173 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag PHA55_RS05080 Protein ID WP_000615982.1
Coordinates 1066632..1066910 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PHA55_RS05085 Protein ID WP_000729704.1
Coordinates 1066913..1067173 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS05065 (1064214) 1064214..1064792 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PHA55_RS05070 (1064998) 1064998..1065765 + 768 WP_000333380.1 class II glutamine amidotransferase -
PHA55_RS05075 (1065736) 1065736..1066476 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PHA55_RS05080 (1066632) 1066632..1066910 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PHA55_RS05085 (1066913) 1066913..1067173 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PHA55_RS05090 (1067359) 1067359..1068132 + 774 WP_000543899.1 C40 family peptidase -
PHA55_RS05095 (1068189) 1068189..1068545 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
PHA55_RS05100 (1068538) 1068538..1068816 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
PHA55_RS05105 (1068921) 1068921..1071014 - 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
PHA55_RS05110 (1070998) 1070998..1072137 - 1140 WP_032216948.1 flagellar type III secretion system protein FlhB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T267698 WP_000615982.1 NZ_CP116044:c1066910-1066632 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT267698 WP_000729704.1 NZ_CP116044:c1067173-1066913 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References