Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 197312..197914 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PHA55_RS00965 Protein ID WP_000897305.1
Coordinates 197312..197623 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PHA55_RS00970 Protein ID WP_000356397.1
Coordinates 197624..197914 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS00940 (193226) 193226..193825 + 600 WP_001295269.1 glucose-1-phosphatase -
PHA55_RS00945 (193819) 193819..194691 + 873 WP_000920762.1 virulence factor BrkB family protein -
PHA55_RS00950 (194688) 194688..195125 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PHA55_RS00955 (195170) 195170..196111 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PHA55_RS00960 (196175) 196175..197083 - 909 WP_001162704.1 alpha/beta hydrolase -
PHA55_RS00965 (197312) 197312..197623 + 312 WP_000897305.1 hypothetical protein Toxin
PHA55_RS00970 (197624) 197624..197914 + 291 WP_000356397.1 NadS family protein Antitoxin
PHA55_RS00975 (198500) 198500..198718 + 219 WP_001315930.1 CopG family transcriptional regulator -
PHA55_RS00980 (198938) 198938..199180 + 243 WP_001087409.1 protein YiiF -
PHA55_RS00985 (199510) 199510..200439 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PHA55_RS00990 (200436) 200436..201071 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PHA55_RS00995 (201068) 201068..201970 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T267695 WP_000897305.1 NZ_CP116044:197312-197623 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT267695 WP_000356397.1 NZ_CP116044:197624-197914 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References