Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4801505..4802107 Replicon chromosome
Accession NZ_CP116042
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PGC28_RS23580 Protein ID WP_001159630.1
Coordinates 4801796..4802107 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PGC28_RS23575 Protein ID WP_000362050.1
Coordinates 4801505..4801795 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC28_RS23560 (4798998) 4798998..4799900 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PGC28_RS23565 (4799897) 4799897..4800532 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PGC28_RS23570 (4800529) 4800529..4801458 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PGC28_RS23575 (4801505) 4801505..4801795 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PGC28_RS23580 (4801796) 4801796..4802107 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PGC28_RS23585 (4802325) 4802325..4803254 + 930 WP_001127703.1 alpha/beta hydrolase -
PGC28_RS23590 (4803340) 4803340..4803651 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PGC28_RS23595 (4803648) 4803648..4804094 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PGC28_RS23600 (4804109) 4804109..4805050 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PGC28_RS23605 (4805095) 4805095..4805532 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PGC28_RS23610 (4805529) 4805529..4806401 - 873 WP_000921427.1 virulence factor BrkB family protein -
PGC28_RS23615 (4806395) 4806395..4806994 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T267693 WP_001159630.1 NZ_CP116042:c4802107-4801796 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT267693 WP_000362050.1 NZ_CP116042:c4801795-4801505 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References