267686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2469141..2469663 Replicon chromosome
Accession NZ_CP116042
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PGC28_RS12185 Protein ID WP_000221343.1
Coordinates 2469379..2469663 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PGC28_RS12180 Protein ID WP_000885424.1
Coordinates 2469141..2469389 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC28_RS12155 (2464357) 2464357..2465823 + 1467 WP_000987828.1 hypothetical protein -
PGC28_RS12160 (2466631) 2466631..2467345 + 715 Protein_2379 helix-turn-helix domain-containing protein -
PGC28_RS12165 (2467401) 2467401..2468309 - 909 WP_010989018.1 hypothetical protein -
PGC28_RS12170 (2468452) 2468452..2468784 - 333 WP_000253154.1 DUF1493 family protein -
PGC28_RS12175 (2468774) 2468774..2468989 - 216 WP_000206207.1 hypothetical protein -
PGC28_RS12180 (2469141) 2469141..2469389 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PGC28_RS12185 (2469379) 2469379..2469663 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGC28_RS12190 (2469834) 2469834..2470223 + 390 WP_000194089.1 RidA family protein -
PGC28_RS12195 (2470275) 2470275..2471354 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PGC28_RS12200 (2471547) 2471547..2472035 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PGC28_RS12205 (2472080) 2472080..2473588 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2464360..2476445 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T267686 WP_000221343.1 NZ_CP116042:2469379-2469663 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT267686 WP_000885424.1 NZ_CP116042:2469141-2469389 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References