Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3179849..3180434 Replicon chromosome
Accession NZ_CP116040
Organism Acinetobacter haemolyticus strain HW-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PGW89_RS14655 Protein ID WP_113997133.1
Coordinates 3180114..3180434 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PGW89_RS14650 Protein ID WP_005082538.1
Coordinates 3179849..3180121 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGW89_RS14630 (PGW89_14630) 3175871..3176371 + 501 WP_113997971.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PGW89_RS14635 (PGW89_14635) 3176371..3176706 + 336 WP_005082534.1 hydroxyisourate hydrolase -
PGW89_RS14640 (PGW89_14640) 3176754..3178130 + 1377 WP_113997131.1 nucleobase:cation symporter-2 family protein -
PGW89_RS14645 (PGW89_14645) 3178313..3179608 + 1296 WP_113997132.1 hypothetical protein -
PGW89_RS14650 (PGW89_14650) 3179849..3180121 - 273 WP_005082538.1 NadS family protein Antitoxin
PGW89_RS14655 (PGW89_14655) 3180114..3180434 - 321 WP_113997133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGW89_RS14660 (PGW89_14660) 3180618..3181775 - 1158 WP_113997134.1 FAD-dependent urate hydroxylase HpxO -
PGW89_RS14665 (PGW89_14665) 3181957..3182667 - 711 WP_005082543.1 FadR/GntR family transcriptional regulator -
PGW89_RS14670 (PGW89_14670) 3182834..3183838 + 1005 WP_113997135.1 allantoicase -
PGW89_RS14675 (PGW89_14675) 3184084..3184587 + 504 WP_113997136.1 ureidoglycolate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12167.13 Da        Isoelectric Point: 7.8145

>T267675 WP_113997133.1 NZ_CP116040:c3180434-3180114 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELISDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITKDDQIFMLLAY
PKSVKENLTEKETAILCQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10094.53 Da        Isoelectric Point: 8.6797

>AT267675 WP_005082538.1 NZ_CP116040:c3180121-3179849 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References