Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4838530..4839132 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PGH49_RS23890 Protein ID WP_000897302.1
Coordinates 4838821..4839132 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PGH49_RS23885 Protein ID WP_000356397.1
Coordinates 4838530..4838820 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS23860 (4834603) 4834603..4835505 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PGH49_RS23865 (4835502) 4835502..4836137 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PGH49_RS23870 (4836134) 4836134..4837063 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
PGH49_RS23875 (4837279) 4837279..4837497 - 219 WP_001314326.1 CopG family transcriptional regulator -
PGH49_RS23880 (4837893) 4837893..4838171 - 279 WP_001296612.1 hypothetical protein -
PGH49_RS23885 (4838530) 4838530..4838820 - 291 WP_000356397.1 NadS family protein Antitoxin
PGH49_RS23890 (4838821) 4838821..4839132 - 312 WP_000897302.1 hypothetical protein Toxin
PGH49_RS23895 (4839361) 4839361..4840269 + 909 WP_001774092.1 alpha/beta hydrolase -
PGH49_RS23900 (4840333) 4840333..4841274 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PGH49_RS23905 (4841319) 4841319..4841756 - 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
PGH49_RS23910 (4841753) 4841753..4842625 - 873 WP_000920762.1 virulence factor BrkB family protein -
PGH49_RS23915 (4842619) 4842619..4843218 - 600 WP_001314324.1 glucose-1-phosphatase -
PGH49_RS23920 (4843317) 4843317..4844102 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T267664 WP_000897302.1 NZ_CP116035:c4839132-4838821 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT267664 WP_000356397.1 NZ_CP116035:c4838820-4838530 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References