Detailed information of TA system TA026766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 83227..83815
• Replicon: chromosome
• Accession: NC_017376
• Organism: Helicobacter pylori SNT49

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: G2MCY5
• Locus tag: HPSNT_RS00380
• Protein ID: WP_000921928.1
• Coordinates: 83534..83815 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: G2MCY4
• Locus tag: HPSNT_RS00375
• Protein ID: WP_000065302.1
• Coordinates: 83227..83541 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPSNT_RS00355	78755..79411	+	657	WP_000587422.1	ParA family protein	-
HPSNT_RS00360	79493..79777	+	285	WP_000394643.1	hypothetical protein	-
HPSNT_RS00365	79809..80996	+	1188	WP_000753638.1	hypothetical protein	-
HPSNT_RS00370	81021..82931	-	1911	WP_001162743.1	relaxase/mobilization nuclease domain-containing protein	-
HPSNT_RS00375	83227..83541	+	315	WP_000065302.1	hypothetical protein	Antitoxin
HPSNT_RS00380	83534..83815	+	282	WP_000921928.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPSNT_RS00385	84137..85864	-	1728	WP_001227391.1	type IV secretory system conjugative DNA transfer family protein	-
HPSNT_RS00390	85865..86422	-	558	WP_001167765.1	hypothetical protein	-
HPSNT_RS00395	86423..86713	-	291	WP_000159825.1	hypothetical protein	-
HPSNT_RS00400	86710..87165	-	456	WP_000795456.1	hypothetical protein	-
HPSNT_RS00405	87162..88103	-	942	WP_000625151.1	Flp pilus assembly complex ATPase component TadA	-
HPSNT_RS00410	88093..88398	-	306	WP_014536654.1	hypothetical protein	-
HPSNT_RS00415	88395..88658	-	264	WP_000564646.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	rfbM / rfbD / wbcJ	19737..101596	81859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10918.87 Da
• Isoelectric Point: 9.8257

>T26766 WP_000921928.1 NC_017376:83534-83815 [Helicobacter pylori SNT49]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T26766 NC_017376:83534-83815 [Helicobacter pylori SNT49]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACAAGCGTTGTTGATTGCCTCAAAGAACAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12225.67 Da
• Isoelectric Point: 5.6761

>AT26766 WP_000065302.1 NC_017376:83227-83541 [Helicobacter pylori SNT49]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT26766 NC_017376:83227-83541 [Helicobacter pylori SNT49]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAGAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAAGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Structures

Toxin

• AlphaFold DB: G2MCY5

Antitoxin

• AlphaFold DB: G2MCY4