Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-timR/SymE(toxin)
Location 4198805..4199217 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag PGH49_RS20775 Protein ID WP_000132614.1
Coordinates 4198876..4199217 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name timR
Locus tag -
Coordinates 4198805..4198881 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS20765 (4195417) 4195417..4196886 + 1470 WP_001387312.1 type I restriction-modification system subunit M -
PGH49_RS20770 (4196886) 4196886..4198655 + 1770 WP_001513535.1 restriction endonuclease subunit S -
- (4198805) 4198805..4198881 - 77 NuclAT_8 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_8 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_8 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_8 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_9 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_9 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_9 - Antitoxin
- (4198805) 4198805..4198881 - 77 NuclAT_9 - Antitoxin
PGH49_RS20775 (4198876) 4198876..4199217 + 342 WP_000132614.1 endoribonuclease SymE Toxin
PGH49_RS20780 (4199264) 4199264..4200427 - 1164 WP_224153787.1 DUF1524 domain-containing protein -
PGH49_RS20785 (4200481) 4200481..4201357 - 877 Protein_4067 DUF262 domain-containing protein -
PGH49_RS20790 (4201763) 4201763..4202683 - 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
PGH49_RS20795 (4202868) 4202868..4204148 + 1281 WP_001338077.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4183193..4199217 16024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T267657 WP_000132614.1 NZ_CP116035:4198876-4199217 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT267657 NZ_CP116035:c4198881-4198805 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References