Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4119112..4119370 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PGH49_RS20375 Protein ID WP_000809168.1
Coordinates 4119218..4119370 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4119112..4119169 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS20360 4114941..4116200 - 1260 WP_000494929.1 hypothetical protein -
PGH49_RS20365 4116329..4117822 - 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
PGH49_RS20370 4117842..4118603 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4119112..4119169 - 58 - - Antitoxin
PGH49_RS20375 4119218..4119370 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PGH49_RS20380 4119475..4120605 - 1131 WP_001118464.1 molecular chaperone DnaJ -
PGH49_RS20385 4120694..4122610 - 1917 WP_000516135.1 molecular chaperone DnaK -
PGH49_RS20390 4122982..4123386 + 405 WP_000843687.1 DUF2541 family protein -
PGH49_RS20395 4123412..4124125 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T267656 WP_000809168.1 NZ_CP116035:4119218-4119370 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT267656 NZ_CP116035:c4119169-4119112 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References