Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3807321..3808015 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PGH49_RS18895 Protein ID WP_001263500.1
Coordinates 3807321..3807719 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PGH49_RS18900 Protein ID WP_000554758.1
Coordinates 3807722..3808015 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS18870 (3802686) 3802686..3803144 - 459 WP_001291991.1 xanthine phosphoribosyltransferase -
PGH49_RS18875 (3803405) 3803405..3804862 + 1458 WP_001292999.1 cytosol nonspecific dipeptidase -
PGH49_RS18880 (3804919) 3804919..3805533 - 615 WP_000602124.1 peptide chain release factor H -
PGH49_RS18885 (3805530) 3805530..3806669 - 1140 WP_000521561.1 RNA ligase RtcB family protein -
PGH49_RS18890 (3806859) 3806859..3807311 - 453 WP_001059895.1 GNAT family N-acetyltransferase -
PGH49_RS18895 (3807321) 3807321..3807719 - 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PGH49_RS18900 (3807722) 3807722..3808015 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PGH49_RS18905 (3808067) 3808067..3809122 - 1056 WP_001226168.1 DNA polymerase IV -
PGH49_RS18910 (3809193) 3809193..3810116 - 924 WP_001532973.1 putative lateral flagellar export/assembly protein LafU -
PGH49_RS18915 (3810119) 3810119..3810982 - 864 WP_001169518.1 flagellar motor stator protein MotA -
PGH49_RS18920 (3810995) 3810995..3811711 - 717 WP_000938731.1 FliA/WhiG family RNA polymerase sigma factor -
PGH49_RS18925 (3811731) 3811731..3812198 - 468 WP_000725261.1 flagellar basal body-associated FliL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T267654 WP_001263500.1 NZ_CP116035:c3807719-3807321 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT267654 WP_000554758.1 NZ_CP116035:c3808015-3807722 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References