267652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3579582..3580261 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag PGH49_RS17845 Protein ID WP_000057523.1
Coordinates 3579959..3580261 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag PGH49_RS17840 Protein ID WP_000806442.1
Coordinates 3579582..3579923 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS17830 (3575826) 3575826..3576758 - 933 WP_001538399.1 glutaminase A -
PGH49_RS17835 (3577020) 3577020..3579524 + 2505 WP_000083948.1 copper-exporting P-type ATPase CopA -
PGH49_RS17840 (3579582) 3579582..3579923 - 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
PGH49_RS17845 (3579959) 3579959..3580261 - 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGH49_RS17850 (3580394) 3580394..3581188 + 795 WP_001538398.1 TraB/GumN family protein -
PGH49_RS17855 (3581392) 3581392..3581871 + 480 WP_001538397.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
PGH49_RS17860 (3581908) 3581908..3583560 - 1653 WP_001773867.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
PGH49_RS17865 (3583778) 3583778..3584998 + 1221 WP_001773866.1 fosmidomycin MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T267652 WP_000057523.1 NZ_CP116035:c3580261-3579959 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT267652 WP_000806442.1 NZ_CP116035:c3579923-3579582 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References