267646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1868951..1869453 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PGH49_RS08790 Protein ID WP_000767822.1
Coordinates 1869199..1869453 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PGH49_RS08785 Protein ID WP_001259255.1
Coordinates 1868951..1869202 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS08760 (1864129) 1864129..1865196 - 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PGH49_RS08765 (1865196) 1865196..1866266 - 1071 WP_001538918.1 histidinol-phosphate transaminase -
PGH49_RS08770 (1866263) 1866263..1867567 - 1305 WP_001445483.1 histidinol dehydrogenase -
PGH49_RS08775 (1867573) 1867573..1868472 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
PGH49_RS08780 (1868618) 1868618..1868668 - 51 WP_001364200.1 his operon leader peptide -
PGH49_RS08785 (1868951) 1868951..1869202 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PGH49_RS08790 (1869199) 1869199..1869453 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PGH49_RS08795 (1869536) 1869536..1870360 + 825 WP_000754737.1 SDR family oxidoreductase -
PGH49_RS08800 (1870406) 1870406..1871335 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PGH49_RS08805 (1871550) 1871550..1871612 + 63 WP_010723108.1 membrane protein YoeI -
PGH49_RS08810 (1871602) 1871602..1872960 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T267646 WP_000767822.1 NZ_CP116035:1869199-1869453 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT267646 WP_001259255.1 NZ_CP116035:1868951-1869202 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References